- 2007 – Landed his breakout role as astrophysicist Raj Koothrappali in the CBS sitcom The Big Bang Theory.
- 2012 – Earned his first Screen Actors Guild ensemble nomination alongside the cast of The Big Bang Theory.
- 2015 – Made his New York theatre debut in Jesse Eisenberg’s off-Broadway play The Spoils and published his memoir, Yes, My Accent Is Real.
- 2016 – Made his West End debut when The Spoils transferred to London.
- 2019 – Completed his career-defining run as Raj when The Big Bang Theory concluded after 12 seasons.
- 2020 – Shifted into darker dramatic material with a guest role in Netflix’s interrogation drama Criminal: UK.
- 2021 – Received a BAFTA Television Award nomination for Supporting Actor for Criminal: UK.
- 2022 – Took a prominent post-sitcom role as Aadesh Chopra in the Apple TV+ thriller series Suspicion.